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名稱	ACTICLOT® dPT™ Dilute Time Test
型號
更新時間	2023-09-25
特點	ACTICLOT® dPT™ Dilute Time Test Clinical studies show that a dilute prothrombin time test is an effective LA coagulation assay and can identify LA that are not detected by other tests such。}

詳細內容

品牌	其他品牌	供貨周期	現貨
應用領域	醫(yī)療衛(wèi)生

ACTICLOT® dPT™ Dilute Time Test Clinical studies show that a dilute prothrombin time test is an effective LA coagulation assay and can identify LA that are not detected by other tests such as a lupus-sensitive APTT and a dilute Russell’s Viper Venom test.

ACTICLOT® dPT™ Dilute Time Test ACTICLOT dPT is a fully integrated dilute prothrombin time test for screening and confirming the presence of phospholipid-dependent LA autoantibodies. The screening protocol utilizes an activator reagent that contains a unique formulation of relipidated recombinant human tissue factor and calcium. The use of recombinant tissue factor in the formulation of the dPT test improves the test’s performance. In the confirmatory protocol, a uniquely formulated phospholipid reagent is used to demonstrate the phospholipid-dependent nature of the LA detected in samples that tested positive in the screening protocol.

Clotting is initiated by activating the extrinsic coagulation pathway with tissue factor in the presence of calcium ions. Tissue Factor binds to Factor VIIa resulting in the activation of Factor IX and Factor X. The subsequent conversion of prothrombin to thrombin by Factor Xa initiates clot formation by cleaving fibrinogen to fibrin. Activation of the tissue factor pathway bypasses the intrinsic (contact) pathway and excludes any interference from deficiencies of Factor XII. REF 824

SAMPLES	Citrate collected plasma
SAMPLE PREPARATION	Neat
SAMPLE VOLUME	100 μL of plasma
TOTAL ASSAY TIME	< 5 minutes
NORMAL CLOT TIME	33 – 43 seconds
SENSITIVITY	100%
SPECIFICITY	91%
PRECISION	Intra-assay CV < 4% Inter-assay CV < 5%
NUMBER OF TESTS	240 tests (120 screen/120 confirm)