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名稱	Peprotech公司 Recombinant Human Flt3-Ligand
型號
更新時(shí)間	2023-09-24
特點(diǎn)	Flt3-Ligand是一種生長因子,調(diào)節(jié)早期造血細(xì)胞的增殖。Flt3-Ligand結(jié)合細(xì)胞表達(dá)酪氨酸激酶受體Flt3。Flt3-Ligand,本身不刺激早期造血細(xì)胞的增殖,但synergizes與其他模型和白細(xì)胞介素誘導(dǎo)生長和分化。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human Flt3-Ligand

二.Catalog Number:300-19

三.Synonyms:Fms-related tyrosine kinase 3 ligand

四.Description:

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

五.AA Sequence:

TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

九.Cross Reactivity:Monkey, Mouse, Rat, Human, Leech, Human + Mouse, Rabbit