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名稱	Recombinant Human M-CSF
型號
更新時間	2023-09-24
特點	M-CSF是一個有效的造血因子由多種細胞包括淋巴細胞、單核細胞、成纖維細胞、內皮細胞、成肌細胞和成骨細胞。這是一個細胞增殖的關鍵調節器,分化,和生存的血液單核細胞、組織巨噬細胞。M-CSF臨床上用于治療感染,惡性腫瘤和動脈粥樣硬化。它促進骨髓移植后造血恢復。}

詳細內容

一.產品名稱：Recombinant Human M-CSF/Peprotech M-CSF

二.Catalog Number:AF-300-25

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

九.Cross Reactivity:Monkey, Mouse, Rat, Human