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名稱	Recombinant Human IL-6
型號
更新時間	2023-09-24
特點(diǎn)	重組IL - 6是一種多效性的細(xì)胞因子在宿主防御中起著重要的作用,調(diào)節(jié)免疫和炎癥反應(yīng)。產(chǎn)生的T細(xì)胞,單核細(xì)胞、成纖維細(xì)胞、內(nèi)皮細(xì)胞和角化細(xì)胞,il - 6不同的生物功能。刺激b細(xì)胞分化和產(chǎn)生抗體,synergizes IL-3巨核細(xì)胞發(fā)展生產(chǎn)和血小板,誘發(fā)肝acute-phase蛋白質(zhì)的表達(dá),調(diào)節(jié)骨代謝。il - 6通過il - 6受體信號系統(tǒng),包括兩個鏈,IL-6Rαgp130。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human IL-6/重組IL-6

二.Catalog Number:AF-200-06

三.Synonyms:26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

四.Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and plaet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. Manufactured using all non-animal reagents.

五.AA Sequence:

PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

九.Cross Reactivity:Monkey, Mouse, Rat, Human