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名稱	Recombinant Human IL-4
型號
更新時間	2023-09-24
特點	IL-4是一種多效性的細胞因子,調節(jié)不同的T細胞和B細胞的反應包括細胞增殖、生存和基因表達。以IL-4 cytokine-secretion概要,包括分泌,IL-5,il - 6、il - 10和IL-13體液免疫反應。IL-4的另一個主要功能是調節(jié)免疫球蛋白類切換到IgG1和IgE isotypes。重組人類IL-4 15.1 kDa球狀蛋白質含有130個氨基酸殘基。使用所有無動物生產(chǎn)試劑。}

詳細內(nèi)容

一.產(chǎn)品名稱：Recombinant Human IL-4/重組IL-4

二.Catalog Number:AF-200-04

三.Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)

四.Description:

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues. Manufactured using all non-animal reagents.

五.AA Sequence:

MHKCDITLQE IIKTLNSLTE QKTLCTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

九.Cross Reactivity:Human, Mouse